Recombinant Rat IL6
Cat. No.
Z300085
Unit
Price
$246.00
Specifications
| Description | IL-6 is produced by many different cell types. The main sources in vivo are stimulated monocytes, fibroblasts, and endothelial cells. Macrophages, T cells and B lymphocytes, granulocytes, smooth muscle cells, eosinophils, chondrocytes, osteoblasts, mast cells, glial cells, and keratinocytes also produce IL-6 after stimulation. IL-6 is a member of a family of cytokines, which also includes LIF, CNTF, Oncostatin M, IL-11, and CT-1. All known members of the IL-6 cytokine family induce hepatic expression of acute phase proteins. The IL-6 receptor is expressed on T cells, mitogen-activated B cells, peripheral monocytes and some macrophage and B cell derived tumor cell types. It is not expressed in resting B cells but in resting T cells. The IL-6 receptor is a strongly glycosylated protein of 80 kDa and a length of 449 amino acids. It has been designated CD126. |
| SKU | Z300085 |
| Unit quantity | 10 µg |
| Family | IL-6 Family |
| Aliases |
IL-6, IL6 Recombinant Rat Interleukin-6 (IL6) |
| Gene Symbol | IL6 |
| Gene ID | 24498 |
| Accession Number | P20607 |
| Source | E. coli |
| Species | Rat (R. norvegicus) |
| Appearance | Lyophilized Powder |
| Molecular Weight | 22 kDa |
| Endotoxin Level | <1.0 EU/µg of recombinant protein as determined by the LAL method. |
| Purity | >95% as determined by SDS-PAGE |
| Formulation | Recombinant rat Interleukin-6 was lyophilized from a 0.2 μm filtered PBS solution. |
| Function | The ED(50) was determined by the dose-dependent stimulation of the proliferation of monkey 4MBr-5 cells was found to be in the range of 20-40 ng/mL. |
| Reconstitution | A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
| Storage | The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
| Usage | For research use only. Not for diagnostic or therapeutic use. |
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