AAV Vectors & Virus
As a leader in Adeno-Associated Virus (AAV) technology, abm offers an affordable, comprehensive collection of human, mouse and rat genes cloned into ready-to-use AAV vectors or packaged AAV virus (serotypes 1-11) for gene over-expression studies within a wide range of host cells.
Search our Ready-to-Use Libraries by selecting the appropriate dropdowns and entering the gene name, symbol or accession number:
Advantages of the AAV System:
- Used as a promising candidate for gene therapy
- Does not elicit significant immune responses in vivo
- Broad tropism - tissue specificity with different AAV serotypes
- No integration into the host genome
- Ability to transduce both proliferating and quiescent cells
- Long-term expression in non-dividing cells
Can't find the AAV construct you're looking for? Design your own vector using our Plasmid Planner.
Check out our additional AAV Collections:
Additional Information
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Which serotype should I use?
Try our AAV Serotype Blast Kit or selection of control viruses to optimize your experiments. -
The Adeno-associated Virus(AAV)
Learning resources -
Our AAV infectivity Data Speaks for Itself
EGFP expression in lumbar neuronal cells 4 weeks after intrathecal injection into mice (Left), and seen with β-tubulin (red) and DAPI (blue) overlay (Right). Courtesy of Dr. D Lopes, King's college London.
Documents
Top Publications
| 01 | Hypothalamic stem cells control ageing speed partly through exosomal miRNAs. Zhang, Y et al. Nature 548(7665):52-57 (2017). DOI: 10.1038/nature23282. PubMed: 28746310. |
| 02 | Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway. Li, J., et al J Mol Cell Cardiol. 115:170-178 (2018). doi: 10.1016/j.yjmcc.2018.01.005. |
| 03 | Long Noncoding RNA Kcna2 Antisense RNA Contributes to Ventricular Arrhythmias via Silencing Kcna2 in Rats With Congestive Heart Failure. Wang, L.S., et al. J Am Heart Assoc. 6(12) pii: e005965 (2017). doi: 10.1161/JAHA.117.005965. |
FAQs
| What are the correct concentration units for each recombinant viral particle? |
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For lentiviruses and retroviruses, they are measured in CFU/ml (colony-forming units per millilitre). Transduction with lentiviruses and retroviruses can cause the formation of colonies, which can be quantified for concentration. For AAV the titer is measured as genome copies per mL (GC/mL). Adenoviruses are measured as PFU/ml (plaque-forming units per millilitre). Transduction with adenoviruses will kill packaging cells, forming plaques in the process for quantification. The concentration for all three types of viruses can also be classified as IU/ml (Infectious Units/ml). Ultimately, the units refers to the viral particles and different units reflect the different assays involved.
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| What is the solution that the packaging mix is provided in? |
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10mM Tris-HCl
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