Recombinant Rat IL2 (E. coli)
Cat. No.
Z300195
Unit
Price
$63.00
Specifications
| Description | Rat IL2, also known as T-cell growth factor, is a secreted immunoregulatory cytokine produced by T-cells due to antigenic or mitogenic stimulation. IL2 binds to the IL2 receptor, which is found in T and B cells and natural killer cells, and is composed of three distinct components: the cytokine specific α-chain, and the β– and γc-subunits. Its receptor complex IL2 induces the proliferation of T cells, generation of cytotoxic T lymphocytes (CTLs), proliferation and synthesis of immunoglobulin by B cells, and the survival of natural killer cells. Its heterotrimeric receptor complex is also shared by Interleukin 4 (IL4) and Interleukin 7 (IL7) by its gamma chain, and receptor signalling is essential for its expression and differentiation of regulatory T cells in the immune response. |
| SKU | Z300195 |
| Unit quantity | 5 µg |
| Family | Other Interleukins |
| Aliases | T-cell growth factor |
| Gene Symbol | IL2 |
| Gene ID | 116562 |
| Accession Number | P17108 |
| Source | E. coli |
| Species | Rat (R. norvegicus) |
| Appearance | Lyophilized Powder |
| Molecular Weight | 15.6 kDa |
| Endotoxin Level | <1.0 EU/µg of recombinant protein as determined by the LAL method |
| Purity | >95% as determined by SDS-PAGE |
| Formulation | Lyophilized from a 0.2 µm filtered solution in ammonium acetate and glycerol (with BSA as a carrier protein) |
| Function | The ED50 was 0.04-0.2 ng/mL as determined by a cell proliferation assay |
| Storage | The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
| Usage | For research use only. Not for diagnostic or therapeutic use. |
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