Recombinant Mouse IL11 (E. coli)
Cat. No.
Z200125
Unit
Price
$89.00
Specifications
| Description | IL-11 is secreted by bone marrow stromal cells (fibroblasts) and is produced also by a number of mesenchymal cells. The IL-11 receptor (alpha chain) utilizes gp130 as its signal transducer, which is also a component of other cytokine receptors. The alpha chain of the IL-11 receptor has been identified independently as Etl2. IL-11 promotes primary and secondary immune responses in vitro and in vivo and modulates antigen-specific antibody reactions. IL-11 promotes the proliferation of IL-6 dependent plasmacytoma cell lines in the presence of neutralizing IL6 antibodies. IL-11 also stimulates the T cell dependent development of IgG-secreting B cells in spleen cell cultures. IL-11 inhibits the differentiation of pre-adipocytes. It induces the synthesis of some acute phase proteins by hepatocytes. |
| SKU | Z200125 |
| Unit quantity | 10 µg |
| Family | IL-6 Family |
| Aliases |
IL-11 Recombinant Mouse Interleukin-11 (IL11) |
| Gene Symbol | IL11 |
| Gene ID | 16156 |
| Accession Number | P47873 |
| Source | E. coli |
| Species | Mouse (M. musculus) |
| Appearance | Lyophilized Powder |
| Molecular Weight | 19 kDa |
| Endotoxin Level | <1.0 EU/µg of recombinant protein as determined by the LAL method. |
| Purity | >95% as determined by SDS-PAGE |
| Formulation | Recombinant mouse IL-11 was lyophilized from a 0.2 μm filtered PBS solution. |
| Function | The ED(50) was determined by the dose-dependent proliferation of LLC1 cells and was found to be <0.5ng/mL. |
| Reconstitution | A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
| Storage | The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
| Usage | For research use only. Not for diagnostic or therapeutic use. |
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