Recombinant Human THPO
Cat. No.
Z101515
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| Description | Thrombopoietin, known also as TSF (thrombopoiesis stimulating factor), for mediator substances that function as natural stimulators of megakaryocytopoiesis and thus, promote the differentiation of platelets. Thrombopoietin stimulates an increase in the sizes and numbers of megakaryocytes. It also increases the number of small acetyl-cholinesterase positive cells that are early precursor cells of the megakaryocytic lineage. Thrombopoietin is a protein of 332 amino acids that shows significant homology with Epo (erythropoietin) in its N-terminal domain. A comparison of human and porcine Thrombopoietin sequences shows 83 % identity between the erythropoietin-like domains but only 67 % between the C- terminal domains. |
| SKU | Z101515 |
| Unit quantity | 10 µg |
| Family | HDGF/S-100/EPO(TPO) Families |
| Aliases |
C-mpl ligand, ML, Megakaryocyte colony-stimulating factor, Megakaryocyte growth and development factor, MGDF, Myeloproliferative leukemia virus oncogene ligand |
| Gene Symbol | THPO |
| Gene ID | 7066 |
| Accession Number | P40225 |
| Source | HEK293 cells |
| Species | Human (H. sapiens) |
| Appearance | Lyophilized Powder |
| Molecular Weight | 35 kDa |
| Endotoxin Level | <1.0 EU/µg of recombinant protein as determined by the LAL method |
| Purity | Greater than 95% as observed by SDS-PAGE. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS (pH 7.0) |
| Function | The ED50 as determined by the dose-dependent proliferation of Mo7e cells was found to be in the range of 1-2 ng/mL |
| Reconstitution |
It is recommended to reconstitute the lyophilized Thrombopoietin in sterile PBS containing 0.1% endotoxin-free recombinant HSA. |
| Storage | Lyophilized Thrombopoietin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TPO should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Usage | For research use only. Not for diagnostic or therapeutic use. |
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