Recombinant Human sCD23 (FCER2) (E. coli)
Cat. No.
Z101835
Unit
Price
$246.00
Specifications
| Description | CD23 is a calcium dependent transmembrane glycoprotein which is expressed in many cell types. The cytoplasmic region of the protein has two isoforms the 'a' isoform that participates in IgE-regulated endocytosis, and the 'b' isoform, which is involved in IgE-regulated phagocytosis. It has been found that there are at least four soluble forms of the CD23 protein (sCD23) all of which are produced by the activity of metallo/cysteine proteases. In addition to binding IgE, sCD23 have been shown to promote the activation and differentiation of B-cells and stimulate the release of pro-inflammatory cytokines from monocytes. |
| SKU | Z101835 |
| Unit quantity | 20 µg |
| Family | Other Growth Factors/Cytokines |
| Aliases |
Low affinity immunoglobulin epsilon Fc receptor, BLAST-2, Fc-epsilon-RII, Immunoglobulin E-binding factor, Lymphocyte IgE receptor, CD23, B cell differentiation antigen Recombinant Human C-type Lectin Domain Family 4 Member J (FCER2) |
| Gene Symbol | FCER2 |
| Gene ID | 2208 |
| Accession Number | P06734 |
| Source | E. coli |
| Species | Human (H. sapiens) |
| Appearance | Lyophilized Powder |
| Molecular Weight | 19.5 kDa |
| Endotoxin Level | <1.0 EU/µg of recombinant protein as determined by the LAL method. |
| Purity | >95% as determined by SDS-PAGE |
| Formulation | Lyophilized from a 0.2 µm filtered solution in PBS |
| Function | Measured by its ability to bind in a functional ELISA. Immobilized rhCD23 at 2 µg/mL (100 µL/well) can bind human IgE with a linear range of 0.015Â1 µg/mL. |
| Reconstitution | Reconstitute at 100 µg/mL in sterile PBS |
| Storage | The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
| Usage | For research use only. Not for diagnostic or therapeutic use. |
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