Recombinant Human IL31
Cat. No.
Z100525
Unit
Price
$246.00
Specifications
| Description | IL-31 is a recently discovered helical cytokine, belonging to the gp130/IL-6 cytokine family. The receptors for IL-6 family are type I receptors, and they share a number of common structural motifs, such as the cytokine-binding domain with two pairs of conserved cysteine residues and a WSXWS sequence motif in the extracellular domain. IL-31 is expressed preferentially by activated Th2 CD4+ T cells, signaling through a heterodimeric receptor complex composed of IL-31RA and OSMR. Recent studies in both humans and mice have suggested a link between IL-31/IL-31R expression and skin inflammation although the functional significance of endogenous IL-31/IL-31R interactions in influencing innate and adaptive immune responses remains unknown. |
| SKU | Z100525 |
| Unit quantity | 10 µg |
| Family | Other Interleukins |
| Aliases |
IL-31 Recombinant Human Interleukin-31 (IL31) |
| Gene Symbol | IL31 |
| Gene ID | 386653 |
| Accession Number | Q6EBC2 |
| Source | E. coli |
| Species | Human (H. sapiens) |
| Appearance | Lyophilized Powder |
| Molecular Weight | 18 kDa |
| Endotoxin Level | <1.0 EU/µg of recombinant protein as determined by the LAL method. |
| Purity | >95% as determined by SDS-PAGE |
| Formulation | Recombinant Interleukin-31 was lyophilized from a 0.2 μm filtered PBS solution pH 7.5. |
| Function | The ED(50) was determined by the ability to induce STAT3 activation in U87 MG cells, and was determined to be not less than 7.0 ng/mL. |
| Reconstitution | A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
| Storage | The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
| Usage | For research use only. Not for diagnostic or therapeutic use. |
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