Recombinant Human IL2 (E. coli)
Cat. No.
Z100485
Unit
Price
$89.00
Specifications
| Description | A helical bundle of 4 α-helices, IL2 is an immunoregulatory cytokine that is expressed by CD4+/CD8+ T cells, γδ T cells, B cells, eosinophils and dendritic cells. IL2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. While Human IL2 shares 56% and 66% amino acid sequence identity with mouse and rat IL2, respectively only human and mouse IL2 exhibit cross-species activity. Characteristically, IL2 exerts both autocrine and paracrine activity on T cells. In a regulatory role, IL2 is important for the development, survival, and function of regulatory T cells, it enhances Fas-mediated activation-induced cell death, and it inhibits the development of inflammatory Th17 cells. Recombinant Human IL2 is a non-glycosylated polypeptide that contains one intrachain disulfide bond. |
| SKU | Z100485 |
| Unit quantity | 50 µg |
| Family | Other Interleukins |
| Aliases |
IL-2, T-cell growth factor, TCGF Recombinant Human Interleukin-2 (IL2) |
| Gene Symbol | IL2 |
| Gene ID | 3558 |
| Accession Number | P60568 |
| Source | E. coli |
| Species | Human (H. sapiens) |
| Appearance | Lyophilized Powder |
| Molecular Weight | 15 kDa |
| Endotoxin Level | <1.0 EU/µg of recombinant protein as determined by the LAL method |
| Purity | >95% as determined by SDS-PAGE |
| Formulation | Lyophilized from a 0.2μm filtered solution in Tris and NaCL (pH 8.0) |
| Function | The ED50 as determined by the dose dependent proliferation of human T cells was found to be less than 0.5 ng/mL equivalent to 0.8X10^4IU/μg as calibrated against International standard. |
| Reconstitution | A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
| Storage | The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
| Usage | For research use only. Not for diagnostic or therapeutic use. |
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