Recombinant Human IL17A (E. coli)
Cat. No.
Z100465
Unit
Price
$89.00
Specifications
| Description | The founding member of the IL17 family of cytokines, IL17A plays an important role in antimicrobial and chronic inflammation. All the six IL17 cytokines (IL17A-F) share a cystine knot fold and are secreted as homodimers. Mature human IL17A shares 60% amino acid sequence identity with rat and mouse IL17A. IL17 cytokines bind to two receptors; IL17RA and IL17RC that together form a heterodimer. The receptor heterodimer is preferred by IL17 ligands, and thus, either IL17RA or IL17RC knockouts completely abolish IL17 signalling. Recombinant human IL17A is a non-glycosylated, 32 kDa disulfide-linked homodimer. |
| SKU | Z100465 |
| Unit quantity | 25 µg |
| Family | IL-17 Family |
| Aliases |
IL-17, CTLA-8, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8 |
| Gene Symbol | IL17A |
| Gene ID | 3605 |
| Accession Number | Q16552 |
| Source | E. coli |
| Species | Human (H. sapiens) |
| Appearance | Lyophilized Powder |
| Molecular Weight | 16 kDa |
| Endotoxin Level | <1.0 EU/µg of recombinant protein as determined by the LAL method |
| Purity | >95% as determined by SDS-PAGE |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS (pH 7.5) |
| Function | The ED(50), as determined by the dose-dependent proliferation of induction of IL6 in primary human foreskin fibroblasts was found to be approximately 2.0 ng/mL, corresponding to a specific activity of > 5.0 x 10^5 units/mg |
| Reconstitution |
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
| Storage | The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
| Usage | For research use only. Not for diagnostic or therapeutic use. |
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References
- Tang, A., Caballero, A. R., Bierdeman, M. A., Marquart, M. E., Foster, T. J., Monk, I. R., & O’Callaghan, R. J. "Staphylococcus aureus Superantigen-Like Protein SSL1: A Toxic Protease" Pathogens 8(1):2 (2019). DOI: 10.3390/pathogens8010002.
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