Recombinant Human HCC-1 (CCL14) (E. coli)
Cat. No.
Z100305
Unit
Price
$89.00
Specifications
| Description | Hemofiltrate C-C chemokine (HCC)-1 is a recently described monocyte chemoattractant. CCL14 (also known as HCC-1) belongs to the CC chemokine family. Its mature propeptide is a low-affinity agonist of CCR1 that is converted to a high-affinity agonist of CCR1 and CCR5 on proteolytic processing by serine proteases. Determination of the amino acid sequence of HCC-1 revealed four cysteine residues in positions characteristic of the C-C chemokine family, and comparison with the sequences of other chemokines revealed that HCC-1 was most homologous to MIP-1a. However, several functional properties of HCC-1 were atypical of chemokines. Unlike other chemokines, HCC-1 was expressed constitutively in a number of tissues and was present at high concentrations in normal human plasma. In addition, HCC-1 was reported not to be chemotactic for leukocytes. |
| SKU | Z100305 |
| Unit quantity | 10 µg |
| Family | Chemokine-beta Family (CC) |
| Aliases | C-C motif chemokine 14, Chemokine CC-1, HCC1, HCC-3, HCC-1(1-74), NCC-2, Small-inducible cytokine A14, CCL14, NCC2, SCYA14 |
| Gene Symbol | CCL14 |
| Gene ID | 6358 |
| Accession Number | Q16627 |
| Source | E. coli |
| Species | Human (H. sapiens) |
| Appearance | Lyophilized Powder |
| Molecular Weight | 9 kDa |
| Endotoxin Level | <1.0 EU/µg of recombinant protein as determined by the LAL method. |
| Purity | >95% as determined by SDS-PAGE |
| Formulation | Recombinant HCC-1 was lyophilized from a 0.2 μm filtered 20 mM PB,100 mM NaCl solution pH 7.5. |
| Function | Determined by its ability to chemoattract human monocytes using a concentration range of 2-40 ng/mL. |
| Reconstitution | A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
| Storage | The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
| Usage | For research use only. Not for diagnostic or therapeutic use. |
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