Recombinant Human CXCL11 (E. coli)
Specifications
Description | The CXCL11 belongs to the CXC chemokine family characterized by the presence of one amino acid in between the two NH2-terminal cysteines. CXCL11 is produced by a variety of cells including leukocytes, fibroblasts, and endothelial cells upon stimulation with interferons (IFNs). Simultaneous stimulation of fibroblasts or endothelial cells with IFN-gamma and Interleukin-1b or the TLR3 ligand double-stranded RNA results in a synergistic increase of CXCL11 production. CXCL11 attracts natural killer cells and activated T-helper 1 cells. Like CXCL9 and CXCL10, CXCL11 signals through CXC chemokine receptor 3 (CXCR3). |
SKU | Z100585 |
Unit quantity | 20 µg |
Family | Chemokine-alpha Family (CXC) |
Aliases |
CXCL11, C-X-C motif chemokine 11, Beta-R1, H174, Interferon gamma-inducible protein 9, IP-9, Interferon-inducible T-cell alpha chemoattractant, I-TAC, Small-inducible cytokine B11 Recombinant Human IFN-Inducible T-cell Chemoattractant (CXCL11) |
Gene Symbol | CXCL11 |
Gene ID | 6373 |
Accession Number | O14625 |
Source | E. coli |
Species | Human (H. sapiens) |
Appearance | Lyophilized Powder |
Molecular Weight | 8 kDa |
Endotoxin Level | <1.0 EU/µg of recombinant protein as determined by the LAL method |
Purity | >95% as determined by SDS-PAGE |
Formulation | Lyophilized from a 0.2 μm filtered solution in PB,100 mM NaCl pH 7.5 |
Function | Determined by its ability to chemoattract human T cells using a concentration range of 2.0-10.0 ng/mL |
Reconstitution | A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
Storage | The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
Usage | For research use only. Not for diagnostic or therapeutic use. |
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