Recombinant Human BMP4
Cat. No.
Z100105
Unit
Price
$205.00
Specifications
| Description | BMPs are proteins that act to induce the differentiation of mesenchymal-type cells into chondrocytes and osteoblasts before initiating bone formation. They not only promote the differentiation of cartilage-forming cells and bone-forming cells near sites of fractures but also at ectopic locations. Some BMPs act directly on osteoblasts and promote their maturation while at the same time suppressing myogenous differentiation. Other BMPs promote the conversion of typical fibroblasts into chondrocytes and are capable also of inducing the expression of an osteoblast phenotype in non-osteogenic cell types. Intracellular signalling following engagement of receptors for some BMP proteins has been shown to involve the action of SMAD proteins. BMP4 and BMP7 are also known to be involved in the differentiation of sympathetic neurons. BMP4 is a disulfide linked homodimer that is expressed majorly in the lungs but also found in the kidneys, normal and neoplastic prostate tissues, and prostate cancer cell lines. |
| SKU | Z100105 |
| Unit quantity | 10 µg |
| Family | TGF-beta Super-family |
| Aliases |
BMP-4, BMP-2B, DVR4 Recombinant Human Bone Morphogenetic Protein 4 (BMP4) |
| Gene Symbol | BMP4 |
| Gene ID | 652 |
| Accession Number | P12644 |
| Source | E. coli |
| Species | Human (H. sapiens) |
| Appearance | Lyophilized Powder |
| Molecular Weight | 13 kDa |
| Endotoxin Level | <1.0 EU/µg of recombinant protein as determined by the LAL method |
| Purity | >95% as determined by SDS-PAGE |
| Formulation | Lyophilized from a 0.2 μm filtered solution in Sodium carbonate (pH 9) |
| Function | The ED50 as determined by its ability to induce alkaline phosphatase production in mouse ATDC5 chondrogenic was found to be in the range of 0.1-0.2 ug/mL |
| Reconstitution | A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers. |
| Storage | The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
| Usage | For research use only. Not for diagnostic or therapeutic use. |
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