circRNA Research

abm is the leader in circRNA research and product development. This emerging technology has garnered abm a niche spotlight with circRNA researchers around the world. Our comprehensive product line offers circRNA over-expression vectors, purification kits and enzymes including our unique RNase R enzyme. 
 
circRNAs can be over-expressed in mammalian cells by using non-repetitive regions of reverse complementary sequences - these work to bring the exon-flanking portion of introns in close proximity, thus promoting back-splicing into circRNA. abm offers a collection of over 1000 circRNA over-expressing vectors. These circRNAs have been associated with human disease and can be used in over-expression studies to investigate new roles of circRNA in health.

Search our extensive collection of circRNA products using circAtlas ID or Host Gene:

Resources

  • Introduction to CRISPR
    Quantitative PCR (qPCR)
    PCR Learning Resources
  • circRNA Learning Resources
    circRNA
    circRNA Learning Resources
  • sgRNA Design
    Introduction to NGS
    NGS Learning Resources
  • circRNA expression by vector and detection by qPCR
    circRNA Expression Results
    Supporting Data

Top Publications

RNA circularization diminishes immunogenicity and can extend translation duration in vivo.

Wesselhoeft RA et al.
Molecular Cell. (2019)


doi:  10.1016/j.molcel.2019.02.015

Circ_0001103 alleviates IL-1β-induced chrondrocyte cell injuries by upregulating SIRT1 via targeting miR-375.


Zhang M. et al.
Clinical Immunology (2021)


doi: 10.1016/j.clim.2021.108718

Exosome-transmitted circVMP1 facilitates the progression and cisplatin resistance of non-small cell lung cancer by targeting miR-524-5p-METTL3/SOX2 axis. 

Xie H. et al.
Drug Delivery (2022)


doi: 10.1080/10717544.2022.2057617