Anti-Shc1 (Phospho-Tyr349) Antibody
Cat. No.
Y011316
Unit
100 μg
Price
$299.00
Specifications
| Cat. No. | Y011316 |
| Name | Anti-Shc1 (Phospho-Tyr349) Antibody |
| Clone | Polyclonal |
| Price | $299.00 |
| Unit | 100 μg |
| Category | Polyclonal Antibodies |
| Gene Name | Shc1 |
| Alias | p66 |
| Application | WB,ICC/IF |
| Application Info | WB: 1:500~1:1000 IF:1:100~1:200 |
| Raised In | Rabbit |
| Clonality | Polyclonal |
| Reactivity | Human,Mouse |
| Description | This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] |
| Immunogen | The antibody was produced against synthesized phosphopeptide derived from human Shc1 around the phosphorylation site of tyrosine 349 (H-Q-YP-Y-N). |
| Isotype | IgG |
| Concentration | 100ug/100ul |
| Recommended Dilutions | WB: 1:500~1:1000 IF:1:100~1:200 |
| Storage Buffer | Rabbit IgG in phosphate buffered saline (without Mg<sup>2</sup>+ and Ca<sup>2</sup>+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Condition | This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. |
| Formulation | Liquid |
| Species Reactivity | Human,Mouse |
| Specificity | Shc1 (Phospho-Tyr349) antibody detects endogenous levels of Shc1 only when phosphorylated at tyrosine 349. |
| Purity | Affinity purified |
| Guarantee | abm guarantees that all our Anti-Shc1 (Phospho-Tyr349) Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement. |
| Depositor | SAB Y01 |
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