Anti-Mouse CD106/VCAM-1-Biotin Conjugate Antibody
Cat. No.
Y053647
Unit
100 μg
Price
$425.00
Specifications
| Cat. No. | Y053647 |
| Name | Anti-Mouse CD106/VCAM-1-Biotin Conjugate Antibody |
| Clone | Monoclonal |
| Price | $425.00 |
| Unit | 100 μg |
| Category | Monoclonal Antibodies |
| Gene Name | CD106 VCAM-1 |
| Application | Flow cyt |
| Application Info | • Identification and enumeration of CD106 cells by flow cytometry • Identification of VCAM-1+ cells by immunofluorescence and immunohistochemical staining |
| Raised In | Rat |
| Clonality | Monoclonal |
| Reactivity | Mouse |
| Description | VCAM-1 is an adhesion molecule and a major mediator of the inflammatory response. It is expressed on activated microvascular endothelial cells in response to signals arising from immune responses in infection, graft rejection, tumor recognition and killing. The complementary binding ligand for VCAM-1 is VLA-4/CD49d. In addition to VCAM-1, VLA-4 also recognizes the extracellular matrix molecule fibronectin. This pairing of VCAM-1 and VLA-4 is able to provide a second signal (i.e., non-antigen specific) for T cell stimulation, such as that seen in transplantation. The monoclonal antibody MK-2 has been used in transplant studies to suppress cardiac rejection and induce long-term cardiac graft survival. In addition to inflammatory responses, VCAM-1 has a significant role in hemopoiesis through its ability to retain lymphocyte and myeloid precursors on stromal cells in the marrow and lymphoid organs. CD106/VCAM-1 exists as an integral membrane protein. The M/K-2 monoclonal antibody immunoprecipitates a peptide that gives a single band on SDS-PAGE gels with an apparent Mr of ~100 kDa under reducing conditions and 92 kDa under nonreducing conditions. |
| Immunogen | Affinity purified |
| Isotype | Rat IgG1κ |
| Concentration | 100ug/200ul |
| Recommended Dilutions | • Identification and enumeration of CD106 cells by flow cytometry • Identification of VCAM-1+ cells by immunofluorescence and immunohistochemical staining |
| Storage Buffer | PBS, pH 7.4 with 0.05% sodium azide. |
| Storage Condition | This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. |
| Formulation | Liquid |
| Species Reactivity | Mouse |
| Specificity | CD106/VCAM-1 (~Mr 100-kDa) |
| Purity | Affinity purified |
| Guarantee | abm guarantees that all our Anti-Mouse CD106/VCAM-1-Biotin Conjugate Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement. |
| Depositor | Southernbiotech |
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