Anti-Human p75NTR Antibody
Cat. No.
Y075009
Unit
50 μl
Price
$560.00
Specifications
| Cat. No. | Y075009 |
| Name | Anti-Human p75NTR Antibody |
| Clone | Monoclonal |
| Price | $560.00 |
| Unit | 50 μl |
| Category | Monoclonal Antibodies |
| Application | Other |
| Clonality | Monoclonal |
| Description | p75NTR was originally discovered as a low affinity nerve growth factor receptor. Later it was found that it was the receptor for all neurotrophins. It mediates signals of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. Recently, it has been revealed that p75NTR is not only acts as the receptor for neurotrophins but also the receptor for many other pathological ligands such as prions, rabies virus and amyloid beta. p75NTR also acts as a co-receptor for NOGO which mediates inhibitory signals of myelin associated protein. p75NTR is highly expressed in a number of non-neuronal and neuronal cells including motor neurons during development and also in damaged neurons. FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. |
| Immunogen | Extracellular domain of human p75NTR |
| Concentration | 1ug/ul |
| Recommended Dilutions | A concentration of 1-5 µg/ml is recommended for immunohistochemistry. A concentration of 20 µg/ml is recommended for immunofluorescence and FACS. The optimal working dilution should be determined by the end user. |
| Storage Buffer | PBS, pH 7.4 with 0.02% sodium azide. |
| Formulation | Liquid |
| Specificity | Specificity has been confirmed using a number of techniques as described in the reference by Rogers et al (2006). |
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