Anti-C-mAhi-1 M5 Antibody
Cat. No.
Y030001
Unit
100 μg
Price
$225.00
Specifications
| Cat. No. | Y030001 |
| Name | Anti-C-mAhi-1 M5 Antibody |
| Clone | Monoclonal |
| Price | $225.00 |
| Unit | 100 μg |
| Category | Monoclonal Antibodies |
| Gene Name | AHI-1 |
| Application | WB,IHC,Other |
| Application Info | Application include Western blot analysis (1: 1000-2000 dilution), immunoprecipitation ( 1-2 ug / 200-800 ug protein) and immunostaining of cultured cells (1: 200-1000 dilution). |
| Raised In | Mouse |
| Clonality | Monoclonal |
| Reactivity | Mouse |
| Description | Abelson helper integration site-1 (Ahi-1) is a novel oncogene identified based on its common activation in v-abl and myc-induced murine lymphomas. The murine Ahi-1 gene encodes a unique protein with multiple SH3 binding sites, an SH3 domain and multiple WD40-repeat domains. The conserved human homolog (AHI-1) contains an additional coiled-coil domain in its N-terminal region. Both murine and human Ahi-1/AHI-1 genes encode at least three isoforms and thus this gene is also subject to alternative splicing in normal cells. Expression of Ahi-1/AHI-1 is regulated at multiple stages of hematopoiesis in a highly conserved fashion in mouse and humans. It is highly elevated in certain human lymphoma and leukemia cells, including those from patients with cutaneous T-cell lymphomas (CTCL), BCR-ABL chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). AHI-1 is also to be strongly expressed in embryonic hindbrain and forebrain, and AHI-1 may be required for both cerebellar and cortical development in humans. Defects in AHI-1 are the cause of Joubert syndrome, an autosomal recessive brain congenital malformation. |
| Immunogen | C-mAhi-1 M5 reacts with an epitope in the c-terminal region of mouse Ahi-1 protein. A recombinant mouse Ahi-1 GST fusion protein was used as immunogen. This antibody was purified from supernatant by affinity chromatography. |
| Isotype | IgG1 |
| Concentration | 100ug/100ul |
| Recommended Dilutions |
Application include Western blot analysis (1: 1000-2000 dilution), immunoprecipitation ( 1-2 ug / 200-800 ug protein) and immunostaining of cultured cells (1: 200-1000 dilution). |
| Storage Buffer | PBS, pH 7.4 with 0.02% sodium azide. |
| Storage Condition |
This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. |
| Formulation | Liquid |
| Species Reactivity | Mouse |
| Specificity | Reacts with murine Ahi-1. |
| Purity | Affinity Purified |
| Caution |
For Research Use Only |
| Guarantee |
abm guarantees that all our Anti-C-mAhi-1 M5 Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement. |
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