Anti-Bcr (Phospho-Tyr177) Antibody
Cat. No.
Y011199
Unit
100 μg
Price
$299.00
Specifications
Cat. No. Y011199
Name Anti-Bcr (Phospho-Tyr177) Antibody
Clone N/A
Price $299.00
Unit 100 μg
Category Polyclonal Antibodies
Gene Name BCR
Alias D22S662, CML, PHL, ALL
Application WB,IHC
Application Info WB: 1:500~1:1000 IHC: 1:50~1:100
Raised In Rabbit
Clonality Polyclonal
Reactivity Human,Mouse
Description A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Bcr around the phosphorylation site of tyrosine 177 (P-F-Y-VP-N).
Concentration 1ug/ul
Recommended Dilutions WB: 1:500~1:1000 IHC: 1:50~1:100
Storage Buffer phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Condition This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Formulation Liquid
Species Reactivity Human,Mouse
Specificity Bcr (phospho-Tyr177) antibody detects endogenous levels of Bcr only when phosphorylated at tyrosine 177.
Purity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Guarantee abm guarantees that all our Anti-Bcr (Phospho-Tyr177) Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement.
Depositor SAB Y01
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